Calcium to Phosphorus Proportion, PTH, and you may Limbs Fitness

Calcium to Phosphorus Proportion, PTH, and you may Limbs Fitness

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Estimates from the Ray Peat, PhD: “The new proportion out-of calcium in order to phosphate is very important; for this reason milk and you can parmesan cheese are very worthwhile for weight loss, and blocking putting on weight. For folks who commonly extremely energetic, zero fat whole milk and you may parmesan cheese be more effective, just like the surplus fat fat are not called for.”

“The foodstuffs high from inside the phosphate, according to calcium supplements, are cereals, legumes, meats, and you can fish. Of numerous wishing edibles incorporate additional phosphate. Food having a higher, safer proportion out of calcium supplements so you can phosphate try departs, for example kale, turnip vegetables, and you may beet veggies, and several fresh fruit, milk products, and you will parmesan cheese.”

Br J Nutr

“Totally free unsaturated fatty acids trigger the stress hormonal, and cortisol blocks oxidation of sugar and turns they to your greasy acids and triglycerides. Keeping cortisol and you will fret low is the main material. Staying a top ratio away from calcium supplements to help you phosphate helps oppose pressure metabolism.” “Previous guide is actually demonstrating that continuously phosphate can increase inflammation, tissues atrophy, calcification from bloodstream, disease, dementia, and you will, in general, the fresh process from aging.”

2006 September;96(3):545-52. Higher phosphorus consumption exceedingly and you will negatively apply at California and you will bones k-calorie burning in a serving-dependent trends into the match more youthful ladies. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. California and you may P is each other essential nutrients to have limbs and tend to be proven to apply to probably one of the most very important government off limbs metabolism, parathyroid hormones (PTH). Also nice an effective P consumption, normal of Western diet, would-be deleterious to help you bones through the improved PTH secretion. Few controlled amount-reaction research is available on the consequences of high P consumption during the guy. I studied the new brief-name aftereffects of five P amounts for the California and you will bone metabolism within the 14 match ladies, 20-28 yrs . old, who were randomized in order to four managed studies months; thus per studies subject served since the her own manage. P complement dosage of 0 (placebo), 250, 750 or 1500 milligrams have been pulled, split up into about three dosage inside the research day. The dishes served had been equivalent throughout the for every study go out and you will given 495 milligrams P and you will 250 mg Ca. The latest P dosage inspired the new gel PTH (S-PTH) from inside the a dose-depending styles (P=0.0005). There can be a decrease in gel ionized Ca concentration only from inside the the greatest P dose (P=0.004). This new marker off bones development, bone-particular alkaline phosphatase, diminished (P=0.05) therefore the limbs resorption marker, N-critical telopeptide off collagen variety of I, enhanced in reaction for the P dosages (P=0.05). This managed amount-reaction study indicated that P has an amount-established effect on S-PTH and grows PTH secretion rather whenever California consumption try reduced. Incredibly highest P intake adversely impacts bone metabolic process by the coming down limbs development and growing bones resorption, as the expressed of the bones metabolism indicators.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.

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